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China's Third NMN Cosmetic New Raw Material Coming

Recently, Winkey completed the filing of NMN raw materials. NMN can increase the level of NAD+ in the human body and is considered to be a product with anti-ageing properties. Therefore, NMN has always been promoted by merchants as an “elixir”. However, in China, NMN has not been approved for use in food and medicine, so the filing of NMN cosmetics new raw materials is regarded as a turning point.





Recently, according to the information released by the National Medical Products Administration Cosmetic Raw Material Filing Information Platform, another NMN (β-nicotinamide mononucleotide) raw material has been filed, and the filing person is Shenzhen Winkey Pharmaceutical Research and Development Co., Ltd. (Hereinafter referred to as Winkey).


According to the “Technical Requirements” published by Winkey, the purpose of use of this raw material is anti-wrinkle, skin protectant and antioxidant, which can be used in various skin cosmetics, and the maximum allowable concentration should be less than 3%.


Previously, two companies in China applied for the filing of new NMN cosmetics raw materials in January and March 2022, namely Geneharbor Lifespan Health Technology Co., Ltd. (hereinafter referred to as Geneharbor Lifespan) and Kangying Hongmei (Zhongshan) Biotechnology Co., Ltd. (hereinafter referred to as Kangying Hongmei).


Among them, the technical requirements item submitted by Geneharbor Lifespan shows that the purpose of use of this raw material is a skin protectant, moisturizing agent and antioxidant, which can be used in various cosmetics except for lip products, oral hygiene products and spray products. The maximum allowable concentration is ≤3%.


According to the technical requirements published by Kangying Hongmei, the purpose of this raw material is a skin protectant and moisturizing agent, which can be used in various skin cosmetics. The maximum allowable concentration should be ≤10%.


In contrast, the three have certain differences in the application level, especially since the value range of the maximum allowable concentration is quite different. Why does this happen?


Some Chinese industry insiders have analyzed that “At present, there are not many people studying NMN in China. Each company can only base its own research and understanding, but the general direction is similar.”


As for why the maximum allowable concentration they fill in is so different? “This is declared by the enterprise itself, and it should be because the number of animal experiments conducted by the enterprise at that time was different.” The staff of the Inspection and Quarantine Division of the Chinese Academy of Inspection and Quarantine explained that the impact of different concentrations on the subsequent use in the human body is still unclear. It’s hard to say, it depends on the actual user feedback later.


The scientific name of NMN is “β-nicotinamide mononucleotide”. According to public information, it is the precursor of NAD+ (coenzyme I), which is closely related to energy metabolism, glycolysis, DNA replication and other activities in the human body. Therefore, NMN, which can increase the level of NAD+ in the human body, is considered to be a product with anti-aging functions. Therefore, NMN has always been promoted by merchants as an “elixir”.


However, in China, NMN has not been approved for use in food or medicine. Previously, in 2021, the State Administration for Market Regulation of China issued the Letter on Investigating the Illegal Operation of “elixir”, which clarified that the β-nicotinamide mononucleotide (NMN) cannot be produced and traded as food in China and requires the relevant operators to screen out and conduct a full investigation.


Therefore, the filing of new raw materials for NMN cosmetics is regarded as a turning point in the Chinese market.

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